Diethyl nitrosamine - Genotoxic carcinogen, Carbon Tetrachloride - Hepatotoxic agent that induces oxidative stress, inflammation and fibrosis
Liver Cancer
Genotype
Diethyl nitrosamine, Carbon Tetrachloride
Mechanism
Diethyl nitrosamine - Genotoxic carcinogen, Carbon Tetrachloride - Hepatotoxic agent that induces oxidative stress, inflammation and fibrosis
Phenotype
Locomotor activity,Weakness and Fatigue
Biomarker
Alpha-fetoprotein, ALT, AST, Bilirubin
Gene Expression Markers
MYC, TGF-β1 , KI67 , COL1A1, IL-6, VEGF, AFP
Physiology Changes
Tumor nodules, Cachexia, Fibrosis, Hepatocyte necrosis
Histology Grading Endpoint
Hepatocellular carcinoma nodules, Malignant hepatocytes, Fibrosis and Cirrhosis