top of page
Lupus Nephritis
Loss of Function

Lupus Nephritis

  • Genotype

    Fas

  • Mechanism

    Loss of Function

  • Phenotype

    Locomotor activity, Fatigue, Anxiety, Cognitive impairment, Social withdrawal, Pain

  • Biomarker

    Anti-dsDNA antibodies, Anti-nuclear antibodies, CRP, Creatinine,
    Blood Urea Nitrogen, Proteinuria

  • Gene Expression Markers

    FASLG,CASP8,CASP3, BCL2, BAX, IFNA,IFNB1, 
    IFNG , BAFFCD19 CD20

  • Physiology Changes

    Lethargy, Hyperactive B cells and T cells

  • Histology Grading Endpoint

    Deposition of IgG, IgM, IgA and complement in glomeruli, Mesangial cell proliferation, Proliferation of epithelial cells in Bowman’s capsule
    Indicates severe glomerular injury, Tubular atrophy

bottom of page