Toxic gain function
Lymphoma
Genotype
MYC, BCL-2
Mechanism
Toxic gain function
Phenotype
Hypoactivity, Fatigue, Exploratory activity
Biomarker
Lactate Dehydrogenase, miR-155
Gene Expression Markers
MYC , KI67, GLUT1 , CD19, BAX, BCL2
Physiology Changes
Lymphocytosis, Lymph node size, Anemia
Histology Grading Endpoint
Large atypical lymphocytes, High mitotic index, Diffuse large B-cell infiltration