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Major Depressive Disorder
CUMS -induces a loss of synaptic plasticity, decreased neurogenesis, and increased microglial activation, LPS - induces depression behaviors through chronic neuroinflammation and mitochondrial damage, 5-HTT - Loss of function, 5-HT1A - Loss of function

Major Depressive Disorder

  • Genotype

    Chronic Unpredictable Mild Stress, Lipopolysaccharide (LPS)-Induced , Serotonin Transporter Knockout, 5-HT1A Receptor Knockout

  • Mechanism

    CUMS -induces a loss of synaptic plasticity, decreased neurogenesis, and increased microglial activation, LPS - induces depression behaviors through chronic neuroinflammation and mitochondrial damage, 5-HTT - Loss of function, 5-HT1A - Loss of function

  • Phenotype

    Depression, Anxiety, Anhedonia, Social isolation, Immobility, Cognitive impairment, Fatigue, Sleep disorder

  • Biomarker

    Serotonin (5-HT), Dopamine (DA),  Norepinephrine Cortisol, Leptin, Ghrelin, Insulin resistance

  • Gene Expression Markers

    SLC6A4, HTR1A, TNF-α, IL-6, CRH, NR3C1, Bax, Bcl-2

  • Physiology Changes

    EEG - Theta and Beta activity, Sleep - Reduced REM 

  • Histology Grading Endpoint

    Neuronal shrinkage, Astrocyte activation, White matter disruption

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