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Melanoma
BRAFV600E - Toxic gain function, Deletion of CDKN2A - Loss of function

Melanoma

  • Genotype

    BRAFV600E, Deletion of CDKN2A

  • Mechanism

    BRAFV600E - Toxic gain function, Deletion of CDKN2A - Loss of function

  • Phenotype

    Locomotor activity, Fatigue, Exploratory activity

  • Biomarker

    Lactate Dehydrogenase, S100B

  • Gene Expression Markers

    BRAF , CDKN2A , MEK, CDK4/6 , KI67 , MITF , MMP2/9 

  • Physiology Changes

    Angiogenesis, Cutaneous lesions, Cachexia, Tumor size/volume, growth rate, Pigmentation changes

  • Histology Grading Endpoint

    Increase in pigmentation, Melanocyte hyperplasia, Ulceration and Necrosis

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