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Metabolic Dysfunction Associated Steatohepatitis
High fat diet - causes excessive accumulation of free fatty acids, free cholesterol, and ceramides in hepatocytes

Metabolic Dysfunction Associated Steatohepatitis

  • Genotype

    High fat diet

  • Mechanism

    High fat diet - causes excessive accumulation of free fatty acids, free cholesterol, and ceramides in hepatocytes

  • Phenotype

    Hyperphagia, Locomotor activity, Exploratory behavior, Freeze behavior, Fatigue, Anxiety, Cognitive deficits

  • Biomarker

    ALT, AST, Triglycerides, Total cholesterol

  • Gene Expression Markers

    srebp-1c, fasn, acc1, cd36, tgf-β, col1a1, α-sma, tnf-α, il-6, il-1β

  • Physiology Changes

    Glucose tolerance, Mitochondrial dysfunction

  • Histology Grading Endpoint

    Macrovesicular steatosis, Hepatocyte ballooning degeneration, Fibrosis, Distortion of normal liver architecture

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