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Migraine
CACNA1A - Toxic gain function, ATP1A2 - Loss of function, SCN1A - Toxic gain function, Nitroglycerin - causes vasodilation, results in delayed headache

Migraine

  • Genotype

    CACNA1A, ATP1A2, SCN1A, Nitroglycerin

  • Mechanism

    CACNA1A - Toxic gain function, ATP1A2 - Loss of function, SCN1A - Toxic gain function, Nitroglycerin -  trigeminovascular system, causes vasodilation and results in delayed headache

  • Phenotype

    Exploratory behavior, Sensitivity to heat, light, sound, touch, Anxiety, Locomotor activity

  • Biomarker

    Endothelin-1, Glutamate, Serotonin

  • Gene Expression Markers

    CACNA1A, ATP1A2, SOD, CAT, TRPV1, TRPA1

  • Physiology Changes

    Heart rate variablity, EEG - Slow potential shifts, Event related potentials

  • Histology Grading Endpoint

    Neuronal hypertrophy, Cortical layer disruption,  Microglial activation

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