Loss of Function
Multiple Myeloma
Genotype
PDX - MM cells
Mechanism
Loss of Function
Phenotype
Locomotor activity, Pain sensitivity, Lethargy
Biomarker
M-protein, Free light chains, β2-microglobulin
Gene Expression Markers
CD138/CD38, CCND1 , KI67 , BCL2,MMP9 , IL 6, ABCB1
Physiology Changes
Anemia, Hypercalcemia, Cachexia
Histology Grading Endpoint
Osteolytic lesions, Plasma cell infiltration, Loss of normal hematopoiesis