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Multiple system atrophy
Model promotors - induce a-syn overexpression

Multiple system atrophy

  • Genotype

    PLP,MBP, CNP

  • Mechanism

    Model promotors -  induce 
    a-syn overexpression

  • Phenotype

    Bradykinesia, Muscle rigidity, Posture, Tremors, Sleep disorder

  • Biomarker

    NfL, GFAP, Total tau, Norepinephrine

  • Gene Expression Markers

    PLP1, MBP, CNP, TNF, IL1B

  • Physiology Changes

    Heart rate variablity, Gait speed and Blood Pressure

  • Histology Grading Endpoint

    Cytoplasmic inclusion, Demyelination and Microglial activation 

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