top of page
Narcolepsy
Loss of Function

Narcolepsy

  • Genotype

    Orexin Knockout

  • Mechanism

    Loss of Function

  • Phenotype

    Sleep bout during day, Loss of muscle tone, Sleep fragmentation, Locomotor activity, Circadian rhythm instability, Anxiety

  • Biomarker

    Dopamine, Histamine, Cortisol, Ghrelin

  • Gene Expression Markers

    HCRT, HDC, MCH, DRD2, TH

  • Physiology Changes

    EEG - REM sleep abnormalities, Frequent switching between wake, NREM, and REM, Sleep spindles

  • Histology Grading Endpoint

    Reduced neuronal density in hypothalamus, Reduction in neurogenesis

bottom of page