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Neuromyelitis Optica Spectrum Disorder
Aquaporin-4 - enters the central nervous system (CNS) when the blood-brain barrier is disrupted

Neuromyelitis Optica Spectrum Disorder

  • Genotype

    Aquaporin-4 - Induction

  • Mechanism

    Aquaporin-4 - enters the central nervous system (CNS) when the blood-brain barrier is disrupted

  • Phenotype

    Motor deficits, Visual impairment, Fatigue, Motor cooordination, Pain

  • Biomarker

    Anti-dsDNA antibodies, Anti-nuclear antibodies, CRP, Creatinine,
    Blood Urea Nitrogen, Proteinuria

  • Gene Expression Markers

    GFAP, MBP, NfL, BAFF

  • Physiology Changes

    Lethargy, Paralysis, Breakdown of BBB integrity, Edema

  • Histology Grading Endpoint

    Depletion of astrocytes in affected regions, Perivascular localization, Axonal swelling and degeneration, Loss of myelin sheaths,  Tissue necrosis in spinal cord and optic nerve

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