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Neuropathic Pain
Partial nerve injury - Leads to peripheral neuropathic pain via ectopic excitability, Paclitaxel induced - damage to high diameter myelinated fibers, leading to sensory loss and pain, gdap1 - Loss of function

Neuropathic Pain

  • Genotype

    Partial nerve injury, paclitaxel induced, thermal injury, gdap1

  • Mechanism

    Partial nerve injury - Leads to peripheral neuropathic pain via ectopic excitability, Paclitaxel induced - damage to high diameter myelinated fibers, leading to sensory loss and pain, gdap1 - Loss of function

  • Phenotype

    Touch evoke response, Sensitivity to light, heat and cold, Locomotor activity, Gait abnormalities, Anxiety, Depression

  • Biomarker

    MCP-1, GFAP, cGMP, NfL, Cortisol

  • Gene Expression Markers

    SCN9A, TRPV1, BDNF, NGF, TNF-α, IL-6, GAD1, GABRA1

  • Physiology Changes

    EEG - Theta band activity, Spontaneous activity, Reduced slow wave sleep

  • Histology Grading Endpoint

    Axonal degeneration, Inflammatory cell infiltration, Demyelination of nerve fiber

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