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Non-Small Cell Lung Cancer
Kras - Toxic gain function,EGFR - Toxic gain function, Braf - Toxic gain function, Lkb1 -Loss of function

Non-Small Cell Lung Cancer

  • Genotype

    Kras,EGFR, Braf, Lkb1

  • Mechanism

    Kras - Toxic gain function,EGFR - Toxic gain function, Braf - Toxic gain function, Lkb1 -Loss of function

  • Phenotype

    Locomotor activity,Weakness, Respiratory distress and Fatigue

  • Biomarker

    CEA, Lactate Dehydrogenase, CYFRA 21-1

  • Gene Expression Markers

    KRAS , LKB1 , MEK/ERK , AMPK , mTOR , KI67 , MMP2/9, CCND1

  • Physiology Changes

    Tumor growth rate, Hypoxia, Tumor proliferation, Respiratory efficiency

  • Histology Grading Endpoint

    Tumor nodules(Adenomas), Loss of normal alveolar architecture, Tumor infiltration, Necrosis and Vascular invasion

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