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Osteoporosis
Loss of Function

Osteoporosis

  • Genotype

    Glucocorticoid induction, wnt16 KO

  • Mechanism

     Loss of function

  • Phenotype

    Locomotor activity, Freeze behavior, Fatigue, Endurance

  • Biomarker

    Calcium, Phosphate, Osteocalcin, Osteopontin, β-catenin

  • Gene Expression Markers

    wnt16, lrp5/6, runx2, sp, bglap, alp, col1a1, col10a1, trpv6, calb2

  • Physiology Changes

    Posture, reduced bone strength, altered skeletal integrity, increased fragility

  • Histology Grading Endpoint

    Reduced bone mineral density and osteoblast number, Enlarged marrow spaces, Disorganized bone matrix

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