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Osteosarcoma
Loss of Function and Toxic gain function

Osteosarcoma

  • Genotype

    Cell lines - K7M2

  • Mechanism

    Loss of Function and Toxic gain function

  • Phenotype

     Locomotor activity, Pain, Motor coordination, Anxiety, Social isolation

  • Biomarker

    ALP, Osteocalcin, VEGF, MMP9, CRP, miR-21

  • Gene Expression Markers

    TP53, RB1, BCL2, BAX, TNF-α, SOX 2, GLUT1, OCT4

  • Physiology Changes

    Decreased bone mineral density, Increased tumor volume, Abnormal vascular permeability, Cachexia

  • Histology Grading Endpoint

    Osteoid production, Marked nuclear pleomorphism, Cortical bone erosion, Tumor necrosis, Infiltration of macrophages and immune cells

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