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Ovarian Cancer
Trp53 - Loss of function and Toxic gain function, Rb - Loss of function, Brca1 - Loss of function

Ovarian Cancer

  • Genotype

    Trp53, Rb, Brca1

  • Mechanism

    Trp53 - Loss of function and Toxic gain function, Rb - Loss of function, Brca1 - Loss of function

  • Phenotype

    Lethargy, Exploratory activity, Weight loss

  • Biomarker

    Lactate Dehydrogenase, HE4, IL-6

  • Gene Expression Markers

    P53 , RB1, BRCA1 , KI67, CCND1, PARP1, RAD51  BCL2, BAX , MMP2, VIM/CDH2, CDH1

  • Physiology Changes

    Tumor proliferation, Tumor lesions, Massive ascites accumulation

  • Histology Grading Endpoint

    Epithelial proliferation, Invasive carcinoma, Nuclear pleomorphism

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