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Pancreatic Cancer
Kras mutation - Toxic gain function, p53 mutation - Loss of function

Pancreatic Cancer

  • Genotype

    Kras mutation, p53 mutation

  • Mechanism

    Kras mutation - Toxic gain function, p53 mutation - Loss of function

  • Phenotype

    Locomotor activity, Fatigue, Pain sensitivity

  • Biomarker

    Lactate Dehydrogenase, Amylase, Lipase, CA 19-9

  • Gene Expression Markers

    KRAS, TP53 , MEK, KI67, CCND1, BCL2 , Caspase-3 , MMP2/9 , TGF-β1

  • Physiology Changes

    Tumor growth, Metastasis, Systemic inflammation, Fibrosis

  • Histology Grading Endpoint

    Ductal epithelial hyperplasia, Nuclear atypia, Fibrosis, Desmoplastic stroma formation

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