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Post-Traumatic Stress Disorder
SPS -  Impaired GABAergic neurotransmission, SIM - Reduced cortical development, impaired synaptic plasticity and altered serotonin/dopamine levels

Post-Traumatic Stress Disorder

  • Genotype

    Single Prolonged Stress (SPS), Social isolation models

  • Mechanism

    SPS -  Impaired GABAergic neurotransmission, SIM - Reduced cortical development, impaired synaptic plasticity and altered serotonin/dopamine levels

  • Phenotype

    Anxiety, Conditional Learning, Social isolation, Predator avoidance, Depression

  • Biomarker

    Serotonin, Norepinephrine, Cortisol, ACTH

  • Gene Expression Markers

    CRH , NR3C1 , FKBP5, TNF-α, IL-6, SGK1, SLC6A4, TH

  • Physiology Changes

    Heart Rate, EEG - REM, Gamma and Theta activity

  • Histology Grading Endpoint

    Neuronal loss, Dendritic atrophy, White matter disruption

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