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Prion disease
PrPsc - Toxic gain function and PrPc - Loss of function

Prion disease

  • Genotype

    PrPsc

  • Mechanism

    PrPsc - Toxic gain function and PrPc - Loss of function

  • Phenotype

    Depression, Anxiety, Irritability, Psychosis,Hyperactivity, Insomnia, Spatial learning

  • Biomarker

    PrPᶜ, PrPˢᶜ, MAP2

  • Gene Expression Markers

    GFAP, AIF1, TNF, SYP, MAP2, CD 68

  • Physiology Changes

    EEG - Long term potentiation amplitude (LTP) and Hippocampal neuronal density

  • Histology Grading Endpoint

    Numerous vacuoles in neutrophil, Amyloid plaque aggregation and Loss of neurons

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