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Psychosis
Ketamine, PCP - reduces the function of NMDA receptor,RBM12 - Loss of function, ErbB4 KO - Loss of function

Psychosis

  • Genotype

    Ketamine, PCP, RBM12,  and ErbB4 Knockout

  • Mechanism

    Ketamine, PCP - reduces the function of NMDA receptor,RBM12 - Loss of function, ErbB4 KO - Loss of function

  • Phenotype

    Hyperlocomotion, Seizures, Cognitive impairment, Social isolation, Repetitive behavior, Impulsivity, Psychosis

  • Biomarker

    Tau protein, NfL, NRG1, TNF-α

  • Gene Expression Markers

    HTR2A, ERBB4, IL-6, GRIN1, RBM12

  • Physiology Changes

    EEG - Baseline gamma activity, Reduced slow wave sleep, Abnormal REM pattern, Event related Potential

  • Histology Grading Endpoint

    Synaptic changes, Cortical dysfunction, Reduced white matter integrity

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