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Pulmonary Fibrosis
Bleomycin Induction - cytotoxic agent that causes severe DNA damage, oxidative stress, and subsequent abnormal, persistent fibrotic tissue repair

Pulmonary Fibrosis

  • Genotype

    Bleomycin Induction

  • Mechanism

    Bleomycin Induction - cytotoxic agent that causes severe DNA damage, oxidative stress, and subsequent abnormal, persistent fibrotic tissue repair

  • Phenotype

    Locomotor activity, Tolerance, Feeding behavior, Anxiety, Social isolation, Pain

  • Biomarker

    CTGF, IL-6, SP-D, VEGF

  • Gene Expression Markers

    TGFB1, IL1B, ACTA2, IL1B, IL1B, CDH1, CXCL10, MMP2, NOX4, BAX

  • Physiology Changes

    Dyspnea, Lethargy, Cachexia, Airway resistance, educed oxygen saturation, Increased respiratory rate, Increased pulmonary arterial pressure, Hypertension

  • Histology Grading Endpoint

    Initial epithelial injury, Increased neutrophils, macrophages, lymphocytes, Increased fibroblast proliferation, Dense fibrotic lesions, Thickening of vascular walls

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