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Rare Tumors
Rb1 and Rbl1 - Loss of function

Rare Tumors

  • Genotype

    Rb1 and Rbl1 causes murine retinoblastoma

  • Mechanism

    Rb1 and Rbl1 - Loss of function

  • Phenotype

    Impaired Vision, Exploratory activity, Cognitive impairment

  • Biomarker

    Lactate Dehydrogenase, NSE,S100β, TNF-α 

  • Gene Expression Markers

    Rb1/Rbl1 , E2F1, Ki67, BCL2 , BAX , PAX6 , MMP2/9, VEGF 

  • Physiology Changes

    Hypercellularity, Diffuse infiltration into brain parenchyma, Microvascular proliferation, Necrosis

  • Histology Grading Endpoint

    Retinal progenitor proliferation, Disruption of retinal layers, Rosette formation

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