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Rasmussen's Encephalitis
Kainic Acid - induce seizures

Rasmussen's Encephalitis

  • Genotype

    Kainic Acid

  • Mechanism

    Kainic Acid - induce seizures

  • Phenotype

    Seizures, Locomotor activity, Motor coordination, Cognitive dysfunction, Anxiety, Social isolation, Startle response, Repetitive movements

  • Biomarker

    NSE, S100B, NfL, IL-6, GABA, BDNF

  • Gene Expression Markers

    GRIN1 / GRIN2A, GAD1 / GAD2, GABRA1, TNF-α, BAX, SOD1 / SOD2, CD8A

  • Physiology Changes

    EEG - Increased spike frequency and burst firing, Impaired long-term potentiation, Altered heart rate variability

  • Histology Grading Endpoint

    Extensive pyramidal neuron loss, Shrinkage of hippocampal regions, Thinning of cortical layers, Endothelial damage

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