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Retinal Artery Occlusion
 Rose Bengal Model - causes significant, largely irreversible, loss of visual function

Retinal Artery Occlusion

  • Genotype

    Photochemical thrombosis - Rose Bengal Model

  • Mechanism

     Rose Bengal Model - causes significant, largely irreversible, loss of visual function

  • Phenotype

    Visual Acuity, Optokinetic Response, Optomotor Response, Navigation assay, Contrast sensitivity, Light/Dark Preference Test, Startle response, Feeding behavior

  • Biomarker

    GFAP, IL-6, Glutamate levels, Endothelin-1

  • Gene Expression Markers

    HIF-1α, VEGFA, BAX, NRF2, HMOX1, SOD1 / SOD2, GFAP, GRIN1

  • Physiology Changes

    ERG - Reduced b-wave amplitude, Reduced VEP amplitude, Reduced retinal oxygen levels

  • Histology Grading Endpoint

    Thinning of ganglion cell layer, Inner Retinal Layer Degeneration, Retinal Edema, Obstruction of retinal arteries, Increased astrocytes

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