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Retinal Vein Occlusion
Rose Bengal Model - produces free radicals (reactive oxygen species) and damages endothelial cells, leading to vessel blockage

Retinal Vein Occlusion

  • Genotype

    Photochemical thrombosis - Rose Bengal Model

  • Mechanism

    Rose Bengal Model - produces free radicals (reactive oxygen species) and damages endothelial cells, leading to vessel blockage

  • Phenotype

    Visual Acuity, Optokinetic Response, Optomotor Response, Light Sensitivity, Exploratory behavior, Startle response

  • Biomarker

    ICAM-1, VCAM-1, MDA, NSE, Fibrinogen

  • Gene Expression Markers

    HIF-1α, VEGFA, TNF-α, IL-1β, Nrf2, Bax

  • Physiology Changes

    ERG - a-wave amplitude, b-wave amplitude, Oscillatory potentials, Vascular Permeability & Edema

  • Histology Grading Endpoint

    Inner retinal layer swelling, Disorganization of retinal architecture, Retinal ganglion cell (RGC) loss, Thinning of inner retinal layers, Microglial activation and migration

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