Collagen-Induced Arthritis - causes joint swelling, synovitis and bone erosion, prg4b - Loss of function
Rheumatoid Arthritis
Genotype
Collagen-Induced Arthritis, prg4b
Mechanism
Collagen-Induced Arthritis - causes joint swelling, synovitis and bone erosion, prg4b - Loss of function
Phenotype
Reduced locomotor activity, Pain hypersensitivity, Muscle stiffness, Fatigue, Anxiety
Biomarker
Serum Amyloid A, Fibrinogen, CRP, Rheumatoid Factor, Lubricin
Gene Expression Markers
nrf2,sod1,casp3, il10, tgfb1, cxcl8,cxcl10,TNF-α,IL-1β,IL-6,IL-17
Physiology Changes
Swelling, Erythema, Bone erosion, Reduced bone mineral density, Loss of cartilage thickness, Reduced growth
Histology Grading Endpoint
Synovial lining thickening, Immune cell infiltration, Loss of cartilage surface integrity, Fibrillation and erosion, Cortical bone destruction, Invasive granulation tissue