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Seizures
Pentylenetetrazole (PTZ)- GABA antagonist,  Scn1a - Loss of function

Seizures

  • Genotype

    Pentylenetetrazole (PTZ),  Scn1a

  • Mechanism

    Pentylenetetrazole (PTZ)- GABA antagonist,  Scn1a - Loss of function

  • Phenotype

    Hyperactivity, Anxiety, Social isolation, Immobility, Seizure activity - Latency, Frequency, No of seizures, Duration

  • Biomarker

    NSE, Glutamate, GFAP, BDNF

  • Gene Expression Markers

    c-Fos, Bax, Caspase-3, GAD1, GABRA1

  • Physiology Changes

    EEG - Seizure activity - High-amplitude spike-and-wave discharges (SWDs), Interictal spikes and sharp waves

  • Histology Grading Endpoint

    Neuronal loss and Apoptotic cells in hippocampus

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