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Severe alcohol-associated hepatitis
High fat diet + Ethanol - causes Acute steatohepatitis and neutrophil infiltration,ALDH2*2, PNPLA3 - Loss of function

Severe alcohol-associated hepatitis

  • Genotype

    High fat diet + Ethanol, ALDH2*2, PNPLA3

  • Mechanism

    High fat diet + Ethanol - causes Acute steatohepatitis and neutrophil infiltration,ALDH2*2, PNPLA3 - Loss of function

  • Phenotype

    Fatigue, Depression, Cognitive deficits, Anxiety, Motor coordination, Feeding behavior, Addiction, Aggression

  • Biomarker

    AST, ALT, Total bilirubin, Albumin, Acetaldehyde

  • Gene Expression Markers

    Adh1 , Aldh2 , Cyp2e1 , gfb1, Col1a1, Srebp1c, Fasn, Nrf2, Sod, Tnf, Il6, Il1b

  • Physiology Changes

    Hypoglycemia, Body weight, Muscle wasting, Heart rate, Edema

  • Histology Grading Endpoint

    Hepatocyte ballooning, Macrovesicular steatosis, Hepatocyte necrosis, Cellular vacuolation, Perisinusoidal fibrosis

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