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Short Bowel Syndrome
Loss of function

Short Bowel Syndrome

  • Genotype

    CLMP Knockdown

  • Mechanism

    Loss of function

  • Phenotype

    Locomotor activity, Feeding behavior, Fatigue, Anxiety, Stress response

  • Biomarker

    Albumin, Total protein, Ferritin, Lipopolysaccharide, Insulin

  • Gene Expression Markers

    IL 10, muc2, casp3, TNF-α, IL-1β, sox9, cdx2, PEPT1

  • Physiology Changes

    Lethargy, Weight loss, Defecation frequency, Reduced growth, Shortened intestine

  • Histology Grading Endpoint

    Thinning of intestinal wall, Disruption of epithelial lining, Erosion, Submucosal edema, Crypt hyperplasia

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