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Sjögren’s Disease
Loss of Function

Sjögren’s Disease

  • Genotype

     SIL1  KO

  • Mechanism

    Loss of Function

  • Phenotype

    Reduced locomotor activity, Fatigue, Exploratory behavior, Anxiety, Social isolation, Sensory impairment

  • Biomarker

    Aquaporin-5, Caspase-3, Anti-nuclear antibodies

  • Gene Expression Markers

    HSPA5, DDIT3, ATF4, XBP1 , IL6, TNF,IFNG, CXCL13 ,BAX, CASP3, BCL2 

  • Physiology Changes

    Lethargy, ROS production

  • Histology Grading Endpoint

    Dense periductal and perivascular lymphocytic aggregates, Progressive destruction of secretory acinar cells, Ductal epithelial hyperplasia

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