Controlled Cortical Impact - induces focal brain injury via direct mechanical impact
Stroke
Genotype
Endothelin-1
Mechanism
Endothelin-1 - a potent vasoconstrictor that is overexpressed during stroke, primarily contributing to ischemia, neuroinflammation, and BBB breakdown
Phenotype
Locomotor activity, Paralysis, Cognitive deficits, Vision impairment, Motor coordination, Exploratory activity, Sensory motor deficit, Seizures
Biomarker
NfL, GFAP, NSE,S100β
Gene Expression Markers
iba1, cd68, hif-1α, vegf, mmp-9, sod1, ho-1, gpx1
Physiology Changes
Jaw dysmorphism, EEG - Slow-wave activity, Epileptiform discharges
Histology Grading Endpoint
Focal infarct area with neuronal loss, Necrosis, Cytotoxic edema, Reactive gliosis, Neovascularization