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Systemic Hypertension
Angiotensin II (Ang II) Induction - leading to chronic elevation of blood pressure through increased vasoconstriction, sodium retention, and vascular remodeling

Systemic Hypertension

  • Genotype

    Angiotensin II (Ang II) Induction

  • Mechanism

    Angiotensin II (Ang II) Induction - leading to chronic elevation of blood pressure through increased vasoconstriction, sodium retention, and vascular remodeling

  • Phenotype

    Locomotor activity, Fatigue, Anxiety, Light sensitivity, Cognitive impairment, Social interaction

  • Biomarker

    Renin, Aldosterone, Endothelin-1, Creatinine

  • Gene Expression Markers

    agtr1, ren, enos, nox2, bax, bcl2, tgfb1, nrf2,il 6

  • Physiology Changes

    Mean Arterial Pressure, Heart Rate (HR), ECG - Left Ventricular Hypertrophy

  • Histology Grading Endpoint

    Severe medial thickening, Marked lumen narrowing, Fibrosis, Strong inflammatory infiltration,Cardiac hypertrophy, Renal injury like glomerulosclerosis and tubular damage

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