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Systemic Lupus Erythematosus
Bisphenol A - acts as a xenoestrogen and immune-modulator that forces the immune system into an overactive, proinflammatory state

Systemic Lupus Erythematosus

  • Genotype

    Bisphenol A

  • Mechanism

    Bisphenol A - acts as a xenoestrogen and immune-modulator that forces the immune system into an overactive, proinflammatory state

  • Phenotype

    Reduced Locomotor activity, Fatigue, Photosensitivity, Anxiety, Depression,Cognitive impairment, Pain

  • Biomarker

    Complement C3, IFN-α, Anti-dsDNA antibodies, CRP

  • Gene Expression Markers

    IFNA, IFNB1, IFNG , MX1, OAS1,ISG15, BAFF, CD19, CD20 

  • Physiology Changes

    Lethargy, Increased reactive oxygen species

  • Histology Grading Endpoint

    Glomerular immune complex deposition, Mesangial and endocapillary proliferation, Lymphocytes and plasma cells, Vasculitis

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