Toxic gain function
Tauopathies
Genotype
MAPT
Mechanism
Toxic gain function
Phenotype
Spatial learning, Conditional learning, Exploratory behavior, Anxiety, Locomotor activity, Motor coordination
Biomarker
Total Tau, p-Tau, PSD-95
Gene Expression Markers
SYP, DLG4, TNF, IL6, MAP2, TUBB3, CAT
Physiology Changes
EEG - Abnormal oscillations and Cortical thickness
Histology Grading Endpoint
Neurofibrillary tangles, Reduced dendritic branching and Loss of neurons