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Thyroid Eye Disease
Loss of Function

Thyroid Eye Disease

  • Genotype

    dio3b and thrb

  • Mechanism

    Loss of Function

  • Phenotype

    Visual acuity, Impaired eye movements, Sensitivity to light, Activity patterns, Irritability

  • Biomarker

    IGF-1, Creatine kinase, MMP 9, CRP, SAA, Fibronectin

  • Gene Expression Markers

    dio2, TNF-α, IL-6, tgfbr, igf1r, nrf2, casp3

  • Physiology Changes

    Ocular Motility, Edema and inflammation, Increased orbital tissue volume

  • Histology Grading Endpoint

    Infiltration of immune cells, Fibrotic remodeling of muscles, Increased orbital fat volume, Increased vascularity, Distortion of orbital connective tissue

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