top of page
Traumatic Brain Injury
Controlled Cortical Impact - induces focal brain injury via direct mechanical impact

Traumatic Brain Injury

  • Genotype

    Controlled Cortical Impact

  • Mechanism

    Controlled Cortical Impact - induces focal brain injury via direct mechanical impact

  • Phenotype

    Locomotor activity, Anxiety, Thigmotaxis, Cognitive deficits, Touch evoke response, Paralysis, Social isolation

  • Biomarker

    P Tau, NfL, S100β, GFAP

  • Gene Expression Markers

    il-1β, tnf-α, il-6,sod1, gpx1, ho-1, mmp 9, hif-1α

  • Physiology Changes

    EEG - Slow-wave activity, Presence of epileptiform discharges, Reflex responses, Edema

  • Histology Grading Endpoint

    Cortical tissue loss and cavitation, Neuronal degeneration, Reactive gliosis, Axonal swelling

bottom of page