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Tremors
Thy1 - a syn - Toxic gain function

Tremors

  • Genotype

    Thy1 - a syn

  • Mechanism

    Toxic gain function

  • Phenotype

    Tremor - Frequency, Amplitude, Locomotor activity, Motor coordination, Gait abnormalities, Anxiety

  • Biomarker

    Total α-synuclein, NfL,  CRP 

  • Gene Expression Markers

    PGC-1α, SOD1, TH, DAT, DRD2, SNCA

  • Physiology Changes

    EEG - Beta activity, Cortical slowing, Reduced gamma activity

  • Histology Grading Endpoint

    Intraneuronal α-synuclein aggregates, Lewy body inclusions, Microglial activation

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