top of page
Triple Negative Breast Cancer
Toxic gain function and Loss of function

Triple Negative Breast Cancer

  • Genotype

    Cell Line Derived Xenografts - MDA MB-231

  • Mechanism

    Toxic gain function and Loss of function

  • Phenotype

    Fatigue, Hypoactivity, Weight loss, Dyspnea

  • Biomarker

    EGFR, p-ERK, CEA, CA15-3

  • Gene Expression Markers

    KRAS/MAPK , PI3K/AKT , KI67, VIM/CDH2,TWIST1 , CDH1 , MMP 9, VEGF,  EGFR, IL-6, BCL2,Caspase-3 

  • Physiology Changes

    Tumor growth rate, Pulmonary dysfunction, Angiogenesis

  • Histology Grading Endpoint

    Epithelial Proliferation, Loss of normal ductal structure, Stromal reaction, Metastasis

bottom of page