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Type 1 Diabetes
STZ induction - selectively destroying insulin-producing β pancreatic cells through DNA alkylation and oxidative stress

Type 1 Diabetes

  • Genotype

    STZ induction

  • Mechanism

    STZ induction - selectively destroying insulin-producing β pancreatic cells through DNA alkylation and oxidative stress

  • Phenotype

    Locomotor activity, Fatigue, Cognitive deficits, Anxiety, Depression, Pain sensitivity, Exploratory behavior

  • Biomarker

    C-peptide, Insulin, Glucagon, Triglycerides, Fasting blood glucose

  • Gene Expression Markers

    Ins1, Pdx1, Mafa, Pck1, G6pc, Chop, Atf4, Tnf, Il1b

  • Physiology Changes

    Body weight, Heart rate, Hypotension

  • Histology Grading Endpoint

    Reduction in islet size, β-cell depletion, Vacuolation, Hepatic steatosis, Reduced adipocyte size

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