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Type 2 Diabetes
High glucose/ fat diet - increases glycemic load and insulin resistance

Type 2 Diabetes

  • Genotype

    High glucose/ fat diet

  • Mechanism

    High glucose/ fat diet - increases glycemic load and insulin resistance

  • Phenotype

    Locomotor activity, Feeding behavior, Fatigue, Anxiety, Depression, Startle response, Pain sensitivity

  • Biomarker

    Insulin, Triglycerides, Total cholesterol, Fasting blood glucose

  • Gene Expression Markers

    Insr, Irs1, Akt2,Pck1, G6pc, Nrf2, Sod

  • Physiology Changes

    Insulin tolerance, HOMA IR

  • Histology Grading Endpoint

    Islet hypertrophy, Intramyocellular lipid deposition, Hepatocyte ballooning, Inflammatory cell infiltration, Enlarged fat cells

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