DSS - to accelerate the induction of colitis, Mdr1a KO - Loss of function
Ulcerative colitis
Genotype
DSS, Mdr1a KO
Mechanism
DSS - to accelerate the induction of colitis, Mdr1a KO - Loss of function
Phenotype
Locomotor activity, Feeding behavior, Anxiety, Fatigue, Stress response, Irritability
Biomarker
Albumin, P-glycoprotein, CD68, Calprotectin, CRP, SAA
Gene Expression Markers
TNF-α, IL-17, cxcl10, ocln, nrf2, mmp9, gpx1
Physiology Changes
Lethargy, Weight loss, Altered posture, Defecation, Abnormal excretion patterns, Gut permeability, Splenomegaly
Histology Grading Endpoint
Loss of epithelial lining, Surface erosion and ulceration, Crypt shortening, Macrophages and lymphocytes, Loss of mucus layer, Thickening of intestinal wall