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Stargardt Macular Degeneration

ABCA4  -/-

 Phenotype

  • Latency to Light

  • Latency to Moving Objects 

  • Vascular Leakage

  • Reduced Visual cue reaction

  • Reduced color sensitivity

  • Slow Dark Adaptation

Histology

  • Basal linear Deposits

  • Bruch's membrane Thinning

  • Photoreceptor Degeneration

  • Macular atrophy

  • Macular scaring

  • Rod photoreceptor degeneration

  • Neovascularization

Stargardt Macular Degeneration

Biomarkers

  • lipofuscin

  • Electroretinography Amplitude

  • RPE Lipid

  • Vitamin A Dimerization

  • C3

  • Cfb

  • Cfp

  • A2E

  • Creatinine

  • Glutamate

  • Myo-inositol 

  • N-Acetylaspartate

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