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NASH

High Fat, High Carb Induced

 Phenotype

  • Pain Hyperactivity to Abdominal Evoke

  • Early Latency in  Swim Tunnel 

  • Splenomegaly

  • Weight Loss

  • Ascites

Histology

  • Liver Histology Grading (perisinusoidal fibrosis, Inflammation, Ballooning)

  • Macrovesicular Steatosis

  • Hepatic Stellate Cell Differentiation and Bridging fibrosis progress

  • Late Stage Cirrhosis

NASH Research Model

Biomarkers

  • Insulin

  • ROS

  • Serum Fatty Acid

  • Triglycerides

  • Total cholesterol

  • ALT

  • AST

  • GGT

  • Hyaluronic acid

  • Haptoglobin

  • Total bilirubin

  • Laminin

  • TIMP-1

  • Bcl, IL-6, IL-1β, TNFα, CRP, IFNγ 

Type II Diabetes 

High Carb Induced

 Phenotype

  • Elevated Fasting Glucose 

  • Glucose Fed mg/dl  (Elevated OGTT after 30 minutes)

  • Insulin Resistance

  • Obesity

  • Numbness Aversive temperature tolerance

Histology

  • Pancreas with Shrunken Islets

  • Slow Wound Healing Blastema formation rate in days

  • Retinal Necrosis

  • Nephron Necrosis

  • Neuronal Necrosis

Type II Diabetes Research Model

Biomarkers

  • Triglycerides

  • Total Cholesterol

  • Adiponectin

  • Fetuin-A

  • Ceramide

  • CRP

  • IL-6

  • Ferritin

  • Transferrin

  • Apolipoprotein A1

  • MCP-1 

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