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Welcome to Pentagrit !
A fully independent zebrafish screening facility

Adherence to the highest standards of Animal Care

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Current and active accreditations to ensure all experiments follow global and national ethical guidelines

PEOPLE

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 DELIVERING EXCEPTIONAL SERVICES WORLDWIDE

Pentagrit In Numbers

120+

Annual Studies Globally

60

Days to Study Turn Around

90%

Mutant coverage of Human Targets

All

Clinical Assays done in Zebrafish

Publications

  1. Benin Joseph, Kalaichitra P, Bibhas Kar, Vishnupriya D, & Muthulakshmi V. (2026). Method Development and Validation of Short-Chain Brain Sulfatide Using RP-HPLC UV. Asian Journal of Pharmaceutical Research and Development, 14(01), 11–14. https://doi.org/10.22270/ajprd.v14i01.1687

  2. Acton S, O'Donnell MM, Periyasamy K, Dixit B, Eishingdrelo H, Hill C, Paul Ross R, Chesnel L. LPA3 agonist-producing Bacillus velezensis ADS024 is efficacious in multiple neuroinflammatory disease models. Brain Behav Immun. 2024 Oct;121:384-402. doi: 10.1016/j.bbi.2024.08.024. Epub 2024 Aug 13. PMID: 39147172.

  3. Balkrishna A, Rustagi Y, Bhattacharya K, Varshney A. Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras. Biomolecules. 2020 Apr 13;10(4):600. doi: 10.3390/biom10040600. Erratum in: Biomolecules. 2024 Oct 22;14(11):1341. doi: 10.3390/biom14111341. PMID: 32295034; PMCID: PMC7226110.

  4. Selvanathan, Vinola & Karthikeyan, Kittappa & Sharma, Apoorva & Sudheshna, Sai & Mahalaxmi, Sekar. (2021). Anti-inflammatory efficacy of petasin-incorporated zinc oxide eugenol sealer – An in vivo zebrafish study. Journal of Conservative Dentistry. 24. 539. 10.4103/jcd.jcd_433_21.

  5. Balkrishna, Acharya & Nain, Pradeep & Joshi, Monali & Kumar, Brijesh & Varshney, Anurag. (2022). Super-critical fluid extract of Bryonopsis laciniosa (Shivlingi) seeds restores fertility in zebrafish models through revival of cytological and anatomical features. Journal of Ovarian Research. 15. 10.1186/s13048-022-00982-6.

  6. Balkrishna, Acharya & Lochab, Savita & Joshi, Monali & Srivastava, Jyotish & Varshney, Anurag. (2021). Divya-Herbal-Peya Decoction Harmonizes the Inflammatory Response in Lipopolysaccharide-Induced Zebrafish Model. Journal of Experimental Pharmacology. 13. 937-955. 10.2147/JEP.S328864.

  7. Acton, S., Meilin, S., Schulman, Y., Aran, J., Periyasamy, K., and L. Chesnel. ADS024, a single strain live biotherapeutic product, attenuates MOG-EAE induced clinical symptoms in mice and zebrafish. Multiple Sclerosis Journal Volume 29, Issue 3_suppl: MSMilan 2023 Oct 2023 P1459/415 ePoster 2023 SAGE Publications.

  8. S.K., Dr.Prakash. (2023). Immunogenic antitumor potential of Prakasine nanoparticles in zebrafish by gene expression stimulation. Artificial Cells, Nanomedicine, and Biotechnology. 51. 41-56. 10.1080/21691401.2023.2173217.

  9. P K A, Kar B, Roy N, Paira P. Ru(ii)arene(N^N bpy/phen)-based RAPTA complexes for in vitro anti-tumour activity in human glioblastoma cancer cell lines and in vivo toxicity studies in a zebrafish model. RSC Adv. 2022 Jun 29;12(29):18911-18922. doi: 10.1039/d2ra02677e. PMID: 35873312; PMCID: PMC9241057.

  10. Balkrishna A, Verma S, Solleti SK, Khandrika L, Varshney A. Calcio-Herbal Medicine Divya-Swasari-Vati Ameliorates SARS-CoV-2 Spike Protein-Induced Pathological Features and Inflammation in Humanized Zebrafish Model by Moderating IL-6 and TNF-α Cytokines. J Inflamm Res. 2020 Dec 31;13:1219-1243. doi: 10.2147/JIR.S286199. PMID: 33414643; PMCID: PMC7783203.

  11. Balkrishna A, Solleti SK, Verma S, Varshney A. Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation. Molecules. 2020 Nov 2;25(21):5091. doi: 10.3390/molecules25215091. PMID: 33147850; PMCID: PMC7662214.

  12. Balasundaram, Arthi. (2020). Molecular modeling and docking analysis of aspirin with pde7b. Bioinformation. 16. 183-188. 10.6026/97320630016183.

  13. Balkrishna A, Solleti SK, Verma S, Varshney A. Validation of a Novel Zebrafish Model of Dengue Virus (DENV-3) Pathology Using the Pentaherbal Medicine Denguenil Vati. Biomolecules. 2020 Jun 28;10(7):971. doi: 10.3390/biom10070971. PMID: 32605167; PMCID: PMC7408079.

  14. S M FMB, Chitra K, Joseph B, Sundararajan R, S H. Gelidiella acerosa inhibits lung cancer proliferation. BMC Complement Altern Med. 2018 Mar 20;18(1):104. doi: 10.1186/s12906-018-2165-1. PMID: 29558998; PMCID: PMC5861612.

  15. S, Sivamani & Joseph, Joseph. J & Kar, Bibhas. (2014). Anti-inflammatory activity of Withania somnifera leaf extract in stainless steel implant induced inflammation in adult zebrafish. Journal of Genetic Engineering and Biotechnology. 12. 10.1016/j.jgeb.2014.01.002.

  16. S, Sivamani & Joseph, Joseph. J & K, Nishwetha & Kar, Bibhas. (2013). Zebrafish as a model for bioavailability testing of counter drug. International Journal of Drug Development & Research. 5. 159-163.

  17. S. Sivamani, B. Joseph, and B. Kar. “ZEBRAFISH: AN EMERGING MODEL SYSTEM FOR DRUG DISCOVERY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 4, July 2016, pp. 11-14, https://innovareacademics.in/journals/index.php/ajpcr/article/view/9861

  18. S, Sivamani & Kar, Bibhas. (2013). Adult zebrafish as a new animal model to study anxiety. Asian Journal of Experimental Biological Sciences. 4. 167-171.

  19. S, Sivamani & Joseph, Joseph. J & Kar, Bibhas. (2013). Zebrafish: An in vivo model for the study of liposome mediated drug delivery.. International Journal of Molecular Genetics. 3. 53-61.

  20. Bibhas Kar, Sivamani Subbiah. (2013). Zebrafish: An in Vivo Model for the Study of Human Diseases. International Journal of Genetics and Genomics, 1(1), 6-11. https://doi.org/10.11648/j.ijgg.20130101.12

3 Great Questions in
ALS Discovery

December, 2025
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Dr. John Dirk Vestergaard Nieland on our latest issue.
Pentagrit December Magazine_page-0001_ed

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Pentagrit

66, VOC Street, IIT Park, Chennai,

India  - 600100

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