Welcome to Pentagrit !
A fully independent zebrafish screening facility
Adherence to the highest standards of Animal Care


Current and active accreditations to ensure all experiments follow global and national ethical guidelines
PEOPLE

DELIVERING EXCEPTIONAL SERVICES WORLDWIDE
Pentagrit In Numbers
120+
Annual Studies Globally
60
Days to Study Turn Around
90%
Mutant coverage of Human Targets
All
Clinical Assays done in Zebrafish
Publications
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Benin Joseph, Kalaichitra P, Bibhas Kar, Vishnupriya D, & Muthulakshmi V. (2026). Method Development and Validation of Short-Chain Brain Sulfatide Using RP-HPLC UV. Asian Journal of Pharmaceutical Research and Development, 14(01), 11–14. https://doi.org/10.22270/ajprd.v14i01.1687
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Acton S, O'Donnell MM, Periyasamy K, Dixit B, Eishingdrelo H, Hill C, Paul Ross R, Chesnel L. LPA3 agonist-producing Bacillus velezensis ADS024 is efficacious in multiple neuroinflammatory disease models. Brain Behav Immun. 2024 Oct;121:384-402. doi: 10.1016/j.bbi.2024.08.024. Epub 2024 Aug 13. PMID: 39147172.
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Balkrishna A, Rustagi Y, Bhattacharya K, Varshney A. Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras. Biomolecules. 2020 Apr 13;10(4):600. doi: 10.3390/biom10040600. Erratum in: Biomolecules. 2024 Oct 22;14(11):1341. doi: 10.3390/biom14111341. PMID: 32295034; PMCID: PMC7226110.
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Selvanathan, Vinola & Karthikeyan, Kittappa & Sharma, Apoorva & Sudheshna, Sai & Mahalaxmi, Sekar. (2021). Anti-inflammatory efficacy of petasin-incorporated zinc oxide eugenol sealer – An in vivo zebrafish study. Journal of Conservative Dentistry. 24. 539. 10.4103/jcd.jcd_433_21.
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Balkrishna, Acharya & Nain, Pradeep & Joshi, Monali & Kumar, Brijesh & Varshney, Anurag. (2022). Super-critical fluid extract of Bryonopsis laciniosa (Shivlingi) seeds restores fertility in zebrafish models through revival of cytological and anatomical features. Journal of Ovarian Research. 15. 10.1186/s13048-022-00982-6.
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Balkrishna, Acharya & Lochab, Savita & Joshi, Monali & Srivastava, Jyotish & Varshney, Anurag. (2021). Divya-Herbal-Peya Decoction Harmonizes the Inflammatory Response in Lipopolysaccharide-Induced Zebrafish Model. Journal of Experimental Pharmacology. 13. 937-955. 10.2147/JEP.S328864.
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Acton, S., Meilin, S., Schulman, Y., Aran, J., Periyasamy, K., and L. Chesnel. ADS024, a single strain live biotherapeutic product, attenuates MOG-EAE induced clinical symptoms in mice and zebrafish. Multiple Sclerosis Journal Volume 29, Issue 3_suppl: MSMilan 2023 Oct 2023 P1459/415 ePoster 2023 SAGE Publications.
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S.K., Dr.Prakash. (2023). Immunogenic antitumor potential of Prakasine nanoparticles in zebrafish by gene expression stimulation. Artificial Cells, Nanomedicine, and Biotechnology. 51. 41-56. 10.1080/21691401.2023.2173217.
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P K A, Kar B, Roy N, Paira P. Ru(ii)arene(N^N bpy/phen)-based RAPTA complexes for in vitro anti-tumour activity in human glioblastoma cancer cell lines and in vivo toxicity studies in a zebrafish model. RSC Adv. 2022 Jun 29;12(29):18911-18922. doi: 10.1039/d2ra02677e. PMID: 35873312; PMCID: PMC9241057.
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Balkrishna A, Verma S, Solleti SK, Khandrika L, Varshney A. Calcio-Herbal Medicine Divya-Swasari-Vati Ameliorates SARS-CoV-2 Spike Protein-Induced Pathological Features and Inflammation in Humanized Zebrafish Model by Moderating IL-6 and TNF-α Cytokines. J Inflamm Res. 2020 Dec 31;13:1219-1243. doi: 10.2147/JIR.S286199. PMID: 33414643; PMCID: PMC7783203.
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Balkrishna A, Solleti SK, Verma S, Varshney A. Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation. Molecules. 2020 Nov 2;25(21):5091. doi: 10.3390/molecules25215091. PMID: 33147850; PMCID: PMC7662214.
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Balasundaram, Arthi. (2020). Molecular modeling and docking analysis of aspirin with pde7b. Bioinformation. 16. 183-188. 10.6026/97320630016183.
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Balkrishna A, Solleti SK, Verma S, Varshney A. Validation of a Novel Zebrafish Model of Dengue Virus (DENV-3) Pathology Using the Pentaherbal Medicine Denguenil Vati. Biomolecules. 2020 Jun 28;10(7):971. doi: 10.3390/biom10070971. PMID: 32605167; PMCID: PMC7408079.
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S M FMB, Chitra K, Joseph B, Sundararajan R, S H. Gelidiella acerosa inhibits lung cancer proliferation. BMC Complement Altern Med. 2018 Mar 20;18(1):104. doi: 10.1186/s12906-018-2165-1. PMID: 29558998; PMCID: PMC5861612.
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S, Sivamani & Joseph, Joseph. J & Kar, Bibhas. (2014). Anti-inflammatory activity of Withania somnifera leaf extract in stainless steel implant induced inflammation in adult zebrafish. Journal of Genetic Engineering and Biotechnology. 12. 10.1016/j.jgeb.2014.01.002.
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S, Sivamani & Joseph, Joseph. J & K, Nishwetha & Kar, Bibhas. (2013). Zebrafish as a model for bioavailability testing of counter drug. International Journal of Drug Development & Research. 5. 159-163.
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S. Sivamani, B. Joseph, and B. Kar. “ZEBRAFISH: AN EMERGING MODEL SYSTEM FOR DRUG DISCOVERY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 4, July 2016, pp. 11-14, https://innovareacademics.in/journals/index.php/ajpcr/article/view/9861
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S, Sivamani & Kar, Bibhas. (2013). Adult zebrafish as a new animal model to study anxiety. Asian Journal of Experimental Biological Sciences. 4. 167-171.
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S, Sivamani & Joseph, Joseph. J & Kar, Bibhas. (2013). Zebrafish: An in vivo model for the study of liposome mediated drug delivery.. International Journal of Molecular Genetics. 3. 53-61.
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Bibhas Kar, Sivamani Subbiah. (2013). Zebrafish: An in Vivo Model for the Study of Human Diseases. International Journal of Genetics and Genomics, 1(1), 6-11. https://doi.org/10.11648/j.ijgg.20130101.12
3 Great Questions in
ALS Discovery
December, 2025
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Dr. John Dirk Vestergaard Nieland on our latest issue.
Reach Us
Pentagrit
66, VOC Street, IIT Park, Chennai,
India - 600100




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